Advanced immunophenotyping: A powerful tool for immune profiling, drug screening, and a personalized treatment approach.

ABSTRACT: Various autoimmune diseases are characterized by distinct cell subset distributions and activation profiles of peripheral blood mononuclear cells (PBMCs). PBMCs can therefore serve as an ideal biomarker material, which is easily accessible and allows for screening of multiple cell types. A detailed understanding of the immune landscape is critical for the diagnosis of patients with autoimmune diseases, as well as for a personalized treatment approach. In our study, we investigate the potential of multi-parameter spectral flow cytometry for the identification of patients suffering from autoimmune diseases and its power as an evaluation tool for in vitro drug screening approaches (advanced immunophenotyping). We designed a combination of two 22-color immunophenotyping panels for profi

SUBMITTER: Preglej T 

PROVIDER: S-EPMC10080106 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature