Microglial activation persists beyond clinical recovery following sport concussion in collegiate athletes.

ABSTRACT:

Introduction

In concussion, clinical and physiological recovery are increasingly recognized as diverging definitions. This study investigated whether central microglial activation persisted in participants with concussion after receiving an unrestricted return-to-play (uRTP) designation using [¹⁸F]DPA-714 PET, an in vivo marker of microglia activation.

Methods

Eight (5 M, 3 F) current athletes with concussion (Group 1) and 10 (5 M, 5 F) healthy collegiate students (Group 2) were enrolled. Group 1 completed a pre-injury (Visit1) screen, follow-up Visit2 within 24 h of a concussion diagnosis, and Visit3 at the time of uRTP. Healthy participants only completed assessments at Visit2 and Visit3. At Visit2, all participants completed a multidimensional battery of

SUBMITTER: Neumann KD 

PROVIDER: S-EPMC10080132 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature