Cellular and systemic energy metabolic dysregulation in asthma development-a hypothesis-generating approach.

ABSTRACT:

Background

The roles of systemic and airway-specific epithelial energy metabolism in altering the developmental programming of airway epithelial cells (AECs) in early life are poorly understood.

Objective

Our aim was to assess carbohydrate metabolism in developing AECs among children with and without wheeze and test the association of infant plasma energy biomarkers with subsequent recurrent wheeze and asthma outcomes.

Methods

We measured cellular carbohydrate metabolism in live nasal AECs collected at age 2 years from 15 male subjects with and without a history of wheeze and performed a principal component analysis to visually assess clustering of data on AEC metabolism of glycolitic metabolites and simple sugars. Among 237 children with available year 1 plasma sampl

SUBMITTER: Berdnikovs S 

PROVIDER: S-EPMC10080213 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature