Paget disease of the breast with underlying invasive ductal cancer in neurofibromatosis type 1: a case report.

ABSTRACT:

Background

Neurofibromatoses (NFs) are a group of rare autosomal dominant genetic disorders characterized by tumors growing in the nervous system. Neurofibromas, which are soft noncancerous tumors, have been found on or under the skin in patients with NF1. Furthermore, patients with NF1 are susceptible to various cancers, including breast cancer. Neurofibromas under the skin of the breast can delay the diagnosis of breast cancer, which severely reduces life expectancy. Paget disease of the breast (PDB) is a rare type of breast cancer that causes eczema-like changes of the nipple.

Case description

Here, we present a rare case of a 50-year-old woman who was diagnosed with NF1 and an invasive ductal breast carcinoma accompanied by PDB. The patient underwent mastectomy, sentinel

SUBMITTER: Liu T 

PROVIDER: S-EPMC10080468 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature