Tumor dormancy is closely related to prognosis prediction and tumor immunity in neuroblastoma.

ABSTRACT:

Background

Neuroblastoma (NB), which is the most frequent and fatal solid tumor in early childhood, lacks an accurate approach to prevent or forecast its recurrence. Dormant NB cells are responsible for metastasis, drug resistance, and suppressive activity in the immune system. However, there is a lack of systematic research on the interaction between dormancy and NB prognosis and its potential associations with tumor immunity.

Methods

We downloaded NB gene expression data and clinical information from the Gene Expression Omnibus and ArrayExpres databases. Based on consensus clustering of the expression of dormancy-associated genes, the NB samples were classified into different groups, and differentially expressed genes (DEGs) were explored in each group. Functional analyses

SUBMITTER: Tian X 

PROVIDER: S-EPMC10080482 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature