Narrative review of pediatric heart failure in the age of precision medicine.

ABSTRACT:

Background and objective

Improvement in the affordability and convenience of genetic testing has rapidly expanded the understanding of the mechanistic causes of various pediatric cardiomyopathies. Concurrently, new therapies are being developed to better-target specific pathologies as opposed to classic therapies that treat the maladaptive processes of chronic heart failure. This review will discuss the advances in genetic testing and specific therapies that have been shown to benefit or potentially benefit genetically distinct subsets of the pediatric population with heart failure or at risk of developing heart failure.

Methods

We undertook a comprehensive database search (January 2000-August 2022) of PubMed, utilizing terms 'pediatric', 'cardiomyopathy', 'heart failure', '

SUBMITTER: Valikodath N 

PROVIDER: S-EPMC10080489 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature