Characterization of Mass Transfer within the Crystal-Solution Boundary Layer of l-Alanine {120} Faces Using Laser Interferometry during Growth and Dissolution.

ABSTRACT: Crystallization and dissolution are important processes to consider in drug development as well as many other industrial processes. Many current growth and dissolution models are based on bulk solution properties and do not implicitly consider concentration variation close to the crystal surface-solution interface and how this is mediated by solute diffusive mass transfer. Solution boundary layer thickness and concentration distribution, for the {120} crystal habit face of single crystals of l-alanine in saturated aqueous solutions during both growth and dissolution processes, is measured as a function of super/undersaturation using a Mach-Zehnder optical interferometer system. Further analysis allows determination of the diffusion coefficient and mass flux within the boundary layer as wel

SUBMITTER: Nicholson ST 

PROVIDER: S-EPMC10080658 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature