Surface Area and Local Curvature: Why Roughness Improves the Bioactivity of Neural Implants.

ABSTRACT: While roughening the surface of neural implants has been shown to significantly improve their performance, the mechanism for this improvement is not understood, preventing systematic optimization of surfaces. Specifically, prior work has shown that the cellular response to a surface can be significantly enhanced by coating the implant surface with inorganic nanoparticles and neuroadhesion protein L1, and this improvement occurs even when the surface chemistry is identical between the nanoparticle-coated and uncoated electrodes, suggesting the critical importance of surface topography. Here, we use transmission electron microscopy to characterize the topography of bare and nanoparticle-coated implants across 7 orders of magnitude in size, from the device scale to the atomic scale. The resul

SUBMITTER: Ding R 

PROVIDER: S-EPMC10080668 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature