Dietary supplementation with spray-dried animal plasma improves vaccine protection in aged mice.

ABSTRACT:

Background

Senescence is characterized by an aggravated inflammatory state that reduces vaccine responsiveness. Dietary supplementation with spray-dried porcine plasma (SDP) exerts anti-inflammatory effects in different mucosal areas. We aimed to determine if the anti-inflammatory properties of SDP improve the efficiency of immunization in senescent animals.

Methods

Experiments were performed in 2-month-old and 6-month-old male SAMP8 mice fed control or SDP (8%) feeds for 4  months. The mice received nasal doses of 2.5  μg of Staphylococcus aureus enterotoxin B (SEB) or vehicle every 15  days (i.e., 3 times). Fifteen days after the last dose, a lethal shock was induced by intraperitoneal administration of SEB and LPS.

Results

Immunization increased anti-SEB IgA

SUBMITTER: Miro L 

PROVIDER: S-EPMC10080719 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature