Surface TREM2 on circulating M-MDSCs as a novel prognostic factor for adults with treatment-naive diffuse large B-cell lymphoma.

ABSTRACT:

Introduction

Circulating monocytic myeloid-derived suppressive cells (M-MDSCs) are implicated as a poor prognostic factor and cause CAR T-cell failure in diffuse large B-cell lymphoma (DLBCL). Triggering receptors expressed on myeloid cells 2 (TREM2) are a transmembrane glycoprotein that polarize macrophages to anti-inflammation phenotype but have never been explored on M-MDSCs. This study aims to elucidate the expression and clinical impact of surface TREM2 on circulating M-MDSCs derived from DLBCL adults.

Methods

This prospective, observational study enrolled 100 adults with newly diagnosed and treatment-naïve DLBCL from May 2019 to October 2021. Human circulating M-MDSCs were obtained from freshly isolated peripheral blood, and each patient's surface-TREM2 level on M-MDSC

SUBMITTER: Wang HY 

PROVIDER: S-EPMC10080769 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature