Genetic liability to age at first sex and birth in relation to cardiovascular diseases: a Mendelian randomization study.

ABSTRACT: Growing evidence suggests that various reproductive factors, including early menarche, early menopause, and age at first birth, may increase the risk of developing cardiovascular disease (CVD) later in life. However, the associations between reproductive factors and CVDs are inconsistent and controversial. Therefore, we conducted a two-sample Mendelian randomization (MR) analysis to explore the potential links between age at first sex (AFS) and age at first birth (AFB) and several CVDs. We obtained summary statistics for exposure from the largest genome-wide association studies of AFS and AFB. To serve as instrumental variables, we selected 259 SNPs associated with AFS and 81 SNPs associated with AFB at the genome-wide significance level. We employed a random-effects inverse-variance weigh

SUBMITTER: Chen M 

PROVIDER: S-EPMC10080931 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature