Ancient ubiquitous protein 1 (AUP1) is a prognostic biomarker connected with TP53 mutation and the inflamed microenvironments in glioma.

ABSTRACT:

Introduction

Glioblastoma (GBM) is the most common and lethal brain tumor. The current treatment is surgical removal combined with radiotherapy and chemotherapy, Temozolomide (TMZ). However, tumors tend to develop TMZ resistance which leads to therapeutic failure. Ancient ubiquitous protein 1 (AUP1) is a protein associated with lipid metabolism, which is widely expressed on the surface of ER and Lipid droplets, involved in the degradation of misfolded proteins through autophagy. It has recently been described as a prognostic marker in renal tumors. Here, we aim to use sophisticated bioinformatics and experimental validation to characterize the AUP1's role in glioma.

Material and methods

We collected the mRNA, proteomics, and Whole-Exon-Sequencing from The Cancer Genome Atlas

SUBMITTER: Chang PC 

PROVIDER: S-EPMC10080956 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature