1,6-Hexanediol regulates angiogenesis via suppression of cyclin A1-mediated endothelial function.

ABSTRACT:

Background

Angiogenesis plays important roles in physiological and pathologic conditions, but the mechanisms underlying this complex process often remain to be elucidated. In recent years, liquid-liquid phase separation (LLPS) has emerged as a new concept to explain many cellular functions and diseases. However, whether LLPS is involved in angiogenesis has not been studied until now. Here, we investigated the potential role of LLPS in angiogenesis and endothelial function.

Results

We found 1,6-hexanediol (1,6-HD), an inhibitor of LLPS, but not 2,5-hexanediol (2,5-HD) dramatically decreases neovascularization of Matrigel plug and angiogenesis response of murine corneal in vivo. Moreover, 1,6-HD but not 2,5-HD inhibits microvessel outgrowth of aortic ring and endothelial netwo

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC10080975 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature