The mitochondrial NAD⁺ transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions.

ABSTRACT:

Introduction

Nicotinamide adenine dinucleotide (NAD) is a coenzyme central to metabolism and energy production. NAD⁺-dependent deacetylase sirtuin 3 (SIRT3) regulates the acetylation levels of mitochondrial proteins that are involved in mitochondrial homeostasis. Fasting up-regulates hepatic SIRT3 activity, which requires mitochondrial NAD⁺. What is the mechanism, then, to transport more NAD⁺ into mitochondria to sustain enhanced SIRT3 activity during fasting?

Objective

SLC25A51 is a recently discovered mitochondrial NAD⁺ transporter. We tested the hypothesis that, during fasting, increased expression of SLC25A51 is needed for enhanced mitochondrial NAD⁺ uptake to sustain SIRT3 activity. Because the fasting-fed cycle and

SUBMITTER: Fu Z 

PROVIDER: S-EPMC10080998 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature