The Road Less Traveled: Uncovering the Convergence Toward Specific Pleiotropic Phenotypes in Aging.

ABSTRACT: Aging is a complex process influenced by a wide range of environmental and molecular factors. Despite this complexity, individuals tend to age in highly similar ways, leading to the question of what drives this convergence. Recent research, including my own discoveries, suggests that the length of transcript molecules plays a crucial role in age-dependent changes to the transcriptome. Drawing inspiration from the road trip analogy of cellular transcription, I propose that a non-linear scaling law drives convergence towards specific pleiotropic phenotypes in biological aging. This scaling law is based on the notion that molecular changes observed during aging may reflect unspecific damage to cellular physiology. By validating this hypothesis, I can improve our understanding of biological ag

SUBMITTER: Stoeger T 

PROVIDER: S-EPMC10081180 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature