Sensory neuron LKB1 mediates ovarian and reproductive function.

ABSTRACT: Treatments for reproductive disorders in women primarily consist of hormone replacement therapy, which can have negative health impacts. Bidirectional communication between sensory neurons and innervated organs is an emerging area of interest in tissue physiology with potential relevance for reproductive disorders. Indeed, the metabolic activity of sensory neurons can have profound effects on reproductive phenotypes. To investigate this phenomenon, we utilized a murine model with conditional deletion in sensory neurons of liver kinase B1 (LKB1), a serine/threonine kinase that regulates cellular metabolism. Female mice with this LKB1 deletion (Na _v 1.8cre;LKB1 ^fl/fl ) had significantly more pups per litter compared to wild-type females. Interestingly, the LKB1 genotype

SUBMITTER: Lenert ME 

PROVIDER: S-EPMC10081243 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature