Impact of pathogen genetics on clinical phenotypes in a population of Talaromyces marneffei from Vietnam.

ABSTRACT: Talaromycosis, a severe and invasive fungal infection caused by Talaromyces marneffei , is difficult to treat and impacts those living in endemic regions of southeast Asia, India, and China. While 30% of infections result in mortality, our understanding of the genetic basis of pathogenesis for this fungus is limited. To address this, we apply population genomics and genome wide association study approaches to a cohort of 336 T. marneffei isolates collected from patients who enrolled in the Itraconazole versus Amphotericin B for Talaromycosis (IVAP) trial in Vietnam. We find that isolates from northern and southern Vietnam form two distinct geographical clades, with isolates from southern Vietnam associated with increased disease severity. Leveraging longitudinal isolates, we

SUBMITTER: Sephton-Clark P 

PROVIDER: S-EPMC10081260 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature