Transcription-replication interactions reveal principles of bacterial genome regulation.

ABSTRACT: Organisms determine the transcription rates of thousands of genes through a few modes of regulation that recur across the genome¹. These modes interact with a changing cellular environment to yield highly dynamic expression patterns². In bacteria, the relationship between a gene's regulatory architecture and its expression is well understood for individual model gene circuits^3,4. However, a broader perspective of these dynamics at the genome-scale is lacking, in part because bacterial transcriptomics have hitherto captured only a static snapshot of expression averaged across millions of cells⁵. As a result, the full diversity of gene expression dynamics and their relation to regulatory architecture remains unknown. Here we present a novel genome-

SUBMITTER: Pountain AW 

PROVIDER: S-EPMC10081379 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature