Recovery of inhibitory control prefrontal cortex function in inpatients with heroin use disorder: a 15-week longitudinal fMRI study.

ABSTRACT:

Importance

Heroin addiction and related mortality impose a devastating toll on society, with little known about the neurobiology of this disease or its treatment. Poor inhibitory control is a common manifestation of prefrontal cortex (PFC) impairments in addiction, and its potential recovery following treatment is largely unknown in heroin (or any drug) addiction.

Objective

To study inhibitory control brain activity in iHUD and HC, before and after 15 weeks of inpatient treatment in the former.

Design

A longitudinal cohort study (11/2020-03/2022) where iHUD and HC underwent baseline and follow-up fMRI scans. Average follow-up duration: 15 weeks.

Setting

The iHUD and HC were recruited from treatment facilities and surrounding neighborhoods, respectively.

Part

SUBMITTER: Ceceli AO 

PROVIDER: S-EPMC10081400 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature