A single-nucleus transcriptome-wide association study implicates novel genes in depression pathogenesis.

ABSTRACT:

Background

Depression is a common psychiatric illness and global public health problem. However, our limited understanding of the biological basis of depression has hindered the development of novel treatments and interventions.

Methods

To identify new candidate genes for therapeutic development, we examined single-nucleus RNA sequencing (snucRNAseq) data from the dorsolateral prefrontal cortex (N=424) in relation to ante-mortem depressive symptoms. To complement these direct analyses, we also used genome-wide association study (GWAS) results for depression (N=500,199) along with genetic tools for inferring the expression of 22,159 genes in 7 cell types and 55 cell subtypes to perform transcriptome-wide association studies (TWAS) of depression followed by Mendelian randomiza

SUBMITTER: Zeng L 

PROVIDER: S-EPMC10081415 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature