Testosterone does not shorten action potential duration in Langendorff-perfused rabbit ventricles.

ABSTRACT:

Background

Women have longer baseline QT intervals than men. Because previous studies showed that testosterone and 5α-dihydrotestosterone shorten the ventricular action potential duration (APD) in animal models, differential testosterone concentrations may account for the sex differences in QT interval.

Objective

The purpose of this study was to test the hypothesis that testosterone shortens the APD in Langendorff-perfused rabbit ventricles.

Methods

We performed optical mapping studies in hearts with or without testosterone administration. Acute studies included 26 hearts using 2 different protocols, including 17 without and 9 with atrioventricular (AV) block. For chronic studies, we implanted testosterone pellets subcutaneously in 7 female rabbits for 2-3 weeks befor

SUBMITTER: Ueoka A 

PROVIDER: S-EPMC10081443 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature