Interindividual differences contribute to variation in microbiota composition more than hormonal status: A prospective study.

ABSTRACT:

Aims

Ovarian hormone deficiency is one of the main risk factors for osteoporosis and bone fractures in women, and these risks can be mitigated by menopausal hormone therapy. Recent evidence suggests that gut microbiota may link changes in estrogen levels and bone metabolism. This study was conducted to investigate the potential relationship between hormonal and bone changes induced by oophorectomy and subsequent hormonal therapy and shifts in gut microbiota composition.

Methods

We collected 159 stool and blood samples in several intervals from 58 women, who underwent bilateral oophorectomy. Changes in fecal microbiota were assessed in paired samples collected from each woman before and after oophorectomy or the start of hormone therapy. Bacterial composition was determined b

SUBMITTER: Jackova Z 

PROVIDER: S-EPMC10081494 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature