Disease-Modifying Therapy in Subacute Sclerosing Panencephalitis: An Area of Darkness.

ABSTRACT: Subacute sclerosing panencephalitis (SSPE) is a neurodegenerative disorder because of the persistence of mutated measles virus in the central nervous system. Till date, no curative therapy has been established for SSPE. Multiple drugs have been tried to modify the disease process but have shown mild to moderate benefit at best. It is also challenging to attribute the relative success of some strategies described in single case reports because of the known phenomenon of spontaneous improvement in 5% of patients with SSPE. Critical gaps in understanding the pathophysiological processes involved exist. Current therapies such as interferon alfa require invasive strategies for administration by the intraventricular or intrathecal route, with varying dosage regimens. Oral therapies such as isopr

SUBMITTER: Garg D 

PROVIDER: S-EPMC10081548 | biostudies-literature | 2023 Jan-Feb

REPOSITORIES: biostudies-literature