Experiments on physical ablation of long bone using microwave ablation; defining optimal settings using ex- and in-vivo experiments.

ABSTRACT:

Background

Improved survival of cancer patients leads to more skeletal metastatic lesions that need local therapies for tumor control and pain relief. Not all tumors are radiosensitive and alternative therapies are direly needed. Microwave ablation (MWA) is a technique for minimally invasive local tumor control by physical ablation. In soft tissue local temperature ablation is more common, but studies on bone tissue are limited. To ensure safe and effective treatment, studies on local tumor ablation in bone are needed.

Method

Microwave ablation was performed on sheep bone, for both in- and ex-vivo settings. Both a slow-cooking MWA protocol (gradually increasing wattage in the first two minutes of ablation) and a fast-cooking protocol (no warm-up period) were used. Heat distr

SUBMITTER: Nijland H 

PROVIDER: S-EPMC10081758 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature