Starvation-induced changes in somatic insulin/IGF-1R signaling drive metabolic programming across generations.

ABSTRACT: Exposure to adverse nutritional and metabolic environments during critical periods of development can exert long-lasting effects on health outcomes of an individual and its descendants. Although such metabolic programming has been observed in multiple species and in response to distinct nutritional stressors, conclusive insights into signaling pathways and mechanisms responsible for initiating, mediating, and manifesting changes to metabolism and behavior across generations remain scarce. By using a starvation paradigm in Caenorhabditis elegans, we show that starvation-induced changes in dauer formation-16/forkhead box transcription factor class O (DAF-16/FoxO) activity, the main downstream target of insulin/insulin-like growth factor 1 (IGF-1) receptor signaling, are responsible fo

SUBMITTER: Vogt MC 

PROVIDER: S-EPMC10081852 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature