Could interventions on physical activity mitigate genomic liability for obesity? Applying the health disparity framework in genetically informed studies.

ABSTRACT: Polygenic scores (PGS) are now commonly available in longitudinal cohort studies, leading to their integration into epidemiological research. In this work, our aim is to explore how polygenic scores can be used as exposures in causal inference-based methods, specifically mediation analyses. We propose to estimate the extent to which the association of a polygenic score indexing genetic liability to an outcome could be mitigated by a potential intervention on a mediator. To do this this, we use the interventional disparity measure approach, which allows us to compare the adjusted total effect of an exposure on an outcome, with the association that would remain had we intervened on a potentially modifiable mediator. As an example, we analyse data from two UK cohorts, the Millennium Cohort St

SUBMITTER: Herle M 

PROVIDER: S-EPMC10082115 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature