Safety, biodistribution and radiation dosimetry of [¹²³I]ioflupane in healthy Chinese volunteers.

ABSTRACT:

Background

[¹²³I]ioflupane is a radiopharmaceutical used to visualise the dopaminergic neuron terminals in the striata, to aid in the differential diagnosis among Parkinsonian syndromes (e.g., Parkinson's disease). However, nearly all of the subjects in the initial development studies of [¹²³I]ioflupane were Caucasian.

Methods

8 Chinese healthy volunteers (HVs) received a single 111 MBq ± 10% dose of [¹²³I]ioflupane and had simultaneous whole-body (head to mid-thigh) anterior and posterior planar scintigraphy scans at 10 min and 1, 2, 4, 5, 24, and 48 h. To estimate biodistribution, dosimetry was evaluated for the Cristy-Eckerman female and hermaphrodite male phantoms. Single-photon emission computed tomography (SPECT) images of the brain wer

SUBMITTER: Zhang M 

PROVIDER: S-EPMC10082142 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature