Identification of key genes and immune infiltration based on weighted gene co-expression network analysis in vestibular schwannoma.

ABSTRACT: Vestibular schwannomas are the most common tumors of the cerebellopontine angle, but their pathogenesis is still unclear. This study aimed to explore the molecular mechanisms and potential therapeutic target biomarkers in vestibular schwannoma. Two datasets (GSE141801 and GSE54934) were downloaded from the Gene Expression Omnibus database. Weighted gene coexpression network analysis was performed to find the key modules associated with vestibular schwannoma (VS). Functional enrichment analysis was applied to evaluate the gene enrichment signaling pathway in key modules. Protein-protein interaction networks in key modules were constructed using the STRING website. Hub genes were identified by intersecting candidate hub genes in protein-protein interaction network and candidate hub genes in

SUBMITTER: Fu Y 

PROVIDER: S-EPMC10082262 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature