GATE/Geant4-based dosimetry for ex vivo in solution irradiation of blood with radionuclides.

ABSTRACT: To establish a dose-response relationship between radiation-induced DNA damage and the corresponding absorbed doses in blood irradiated with radionuclides in solution under ex vivo conditions, the absorbed dose coefficient for 1 ml for 1 h internal ex vivo irradiation of peripheral blood (d_Blood) must be determined. d_Blood is specific for each radionuclide, and it depends on the irradiation geometry. Therefore, the aim of this study is to use the Monte Carlo radiation transport code GATE/Geant4 to calculate the mean absorbed dose rates for ex vivo irradiation of blood with several radionuclides used in Nuclear Medicine.

Methods

The Monte Carlo simulation reproduces the irradiation geometry of a blood sample of 7 ml mixed with 1 ml of a water equivalent radioact

SUBMITTER: Salas-Ramirez M 

PROVIDER: S-EPMC10082371 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature