Single-time-point estimation of absorbed doses in PRRT using a non-linear mixed-effects model.

ABSTRACT:

Introduction

Estimation of accurate time-integrated activity coefficients (TIACs) and radiation absorbed doses (ADs) is desirable for treatment planning in peptide-receptor radionuclide therapy (PRRT). This study aimed to investigate the accuracy of a simplified dosimetry using a physiologically-based pharmacokinetic (PBPK) model, a nonlinear mixed effect (NLME) model, and single-time-point imaging to calculate the TIACs and ADs of ⁹⁰Y-DOTATATE in various organs of dosimetric interest and tumors.

Materials & methods

Biokinetic data of ¹¹¹In-DOTATATE in tumors, kidneys, liver, spleen, and whole body were obtained from eight patients using planar scintigraphic imaging at T1 = (2.9 ± 0.6), T2 = (4.6 ± 0.4), T3 = (22.8 ± 1.6), T4 = (46.7 ± 1.7) and T5 = (70

SUBMITTER: Hardiansyah D 

PROVIDER: S-EPMC10082376 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature