Gp130 Promotes Inflammation via the STAT3/JAK2 Pathway in Allergic Conjunctivitis.

ABSTRACT:

Purpose

Allergic conjunctivitis (AC) is a common allergic condition worldwide that requires accurate screening and early diagnosis. We found that gp130 is essential for AC, as gp130 levels are elevated in AC. Therefore, this study aimed to elucidate the functions and the possible underlying mechanisms of gp130 in AC.

Methods

To compare mRNA expression profiles, the conjunctival tissues of BALB/c mice with ovalbumin (OVA)-induced AC were subjected to RNA-sequencing (RNA-seq) analysis followed by bioinformatic analysis. A nonrandomized study involving 57 patients with AC and 24 sex- and age-matched healthy individuals was conducted. A protein chip was used to detect cytokine levels in patient tears. Differentially expressed proteins in patient serum were detected using label-f

SUBMITTER: Bao J 

PROVIDER: S-EPMC10082384 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature