Safety, tolerability, and effectiveness of anticoagulation and antiplatelet therapy in hereditary hemorrhagic telangiectasia.

ABSTRACT:

Background

Antithrombotic therapy (anticoagulation and antiplatelet therapy) is frequently needed in patients with hereditary hemorrhagic telangiectasia (HHT); however, data describing and guiding its use are very limited.

Objectives

To investigate the safety, tolerability, and effectiveness of antithrombotic therapy in HHT in a cohort large enough to compare agents, evaluate for baseline predictors of premature discontinuation, and evaluate hematologic support requirements and healthcare utilization before and after antithrombitc therapy initiation.

Methods

We performed a multicenter observational cohort study characterizing the outcomes of antithrombic therapy in adults with HHT.

Results

A total of 119 patients with HHT with 187 discrete antithrombotic therap

SUBMITTER: Virk ZM 

PROVIDER: S-EPMC10082473 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature