Impact of St. John's wort extract Ze 117 on stress induced changes in the lipidome of PBMC.

ABSTRACT:

Background

Membrane lipids have an important function in the brain as they not only provide a physical barrier segregating the inner and outer cellular environments, but are also involved in cell signaling. It has been shown that the lipid composition effects membrane fluidity which affects lateral mobility and activity of membrane-bound receptors.

Methods

Since changes in cellular membrane properties are considered to play an important role in the development of depression, the effect of St. John's wort extract Ze 117 on plasma membrane fluidity in peripheral blood mononuclear cells (PBMC) was investigated using fluorescence anisotropy measurements. Changes in fatty acid residues in phospholipids after treatment of cortisol-stressed [1 μM] PBMCs with Ze 117 [10-50 µg/ml] we

SUBMITTER: Bussmann H 

PROVIDER: S-EPMC10082490 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature