Quantitative proteomics analysis in small cell carcinoma of cervix reveals novel therapeutic targets.

ABSTRACT:

Background

As a rare pathologic subtype, small cell carcinoma of the cervix (SCCC) is characterized by extensive aggressiveness and resistance to current therapies. To date, our knowledge of SCCC origin and progression is limited and sometimes even controversial. Herein, we explored the whole-protein expression profiles in a panel of SCCC cases, aiming to provide more evidence for the precise diagnosis and targeting therapy.

Methods

Eighteen SCCC samples and six matched normal cervix tissues were collected from January 2013 to December 2017. Data independent acquisition mass spectrometry (DIA) was performed to discriminate the different proteins (DEPs) associated with SCCC. The expression of CDN2A and SYP in corresponding SCCC tissues was verified using immunohistochemistry.

SUBMITTER: Qiu H 

PROVIDER: S-EPMC10082492 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature