The presence, nature and network characteristics of behavioural phenotypes in temporal lobe epilepsy.

ABSTRACT: The relationship between temporal lobe epilepsy and psychopathology has had a long and contentious history with diverse views regarding the presence, nature and severity of emotional-behavioural problems in this patient population. To address these controversies, we take a new person-centred approach through the application of unsupervised machine learning techniques to identify underlying latent groups or behavioural phenotypes. Addressed are the distinct psychopathological profiles, their linked frequency, patterns and severity and the disruptions in morphological and network properties that underlie the identified latent groups. A total of 114 patients and 83 controls from the Epilepsy Connectome Project were administered the Achenbach System of Empirically Based Assessment inventory fr

SUBMITTER: Struck AF 

PROVIDER: S-EPMC10082555 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature