Spared speech fluency is associated with increased functional connectivity in the speech production network in semantic variant primary progressive aphasia.

ABSTRACT: Semantic variant primary progressive aphasia is a clinical syndrome characterized by marked semantic deficits, anterior temporal lobe atrophy and reduced connectivity within a distributed set of regions belonging to the functional network associated with semantic processing. However, to fully depict the clinical signature of semantic variant primary progressive aphasia, it is necessary to also characterize preserved neural networks and linguistic abilities, such as those subserving speech production. In this case-control observational study, we employed whole-brain seed-based connectivity on task-free MRI data of 32 semantic variant primary progressive aphasia patients and 46 healthy controls to investigate the functional connectivity of the speech production network and its relationship w

SUBMITTER: Montembeault M 

PROVIDER: S-EPMC10082556 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature