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Generation of three induced pluripotent stem cell lines to model and investigate diseases affecting Hispanics.

ABSTRACT: Hispanics are the fastest-growing minority group in the United States. There has been a burgeoning interest in understanding the reasons underlying health disparities among this population. To facilitate the modeling and investigation of diseases that differentially impact Hispanics, we generated three induced pluripotent stem cell (iPSC) lines from the peripheral blood mononuclear cells (PBMCs) of healthy Hispanic subjects. All three lines exhibited normal morphology and karyotypes, robust expression of pluripotency markers, and the capacity for trilineage differentiation. The derivatives of these lines will serve as valuable ethnic-appropriate cell sources for further mechanistic studies on diseases impacting Hispanics.

SUBMITTER: Chen IY

PROVIDER: S-EPMC10082602 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Generation of three induced pluripotent stem cell lines to model and investigate diseases affecting Hispanics.

Chen Ian Y IY Olshausen Joseph J Thomas Dilip D Lai Celine C McLaughlin Tracey L TL Wu Joseph C JC

Stem cell research 20221114

Hispanics are the fastest-growing minority group in the United States. There has been a burgeoning interest in understanding the reasons underlying health disparities among this population. To facilitate the modeling and investigation of diseases that differentially impact Hispanics, we generated three induced pluripotent stem cell (iPSC) lines from the peripheral blood mononuclear cells (PBMCs) of healthy Hispanic subjects. All three lines exhibited normal morphology and karyotypes, robust expr ...[more]

PMID: 36427473

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