NOS3 (rs61722009) gene variants testing in prediction of COVID-19 pneumonia severity.

ABSTRACT:

Background

There is a hypothesis that a sufficient level of endothelial nitric oxide synthase is important for reliable protection against COVID-19. Theoretical ideas about the NOS3 gene demonstrated that it can have an effect on links of the complications pathogenesis in COVID-associated pneumonia. We determined the goal - to investigate the association of the NOS3 gene variants with the occurrence of the disease and its clinical course in patients of the intensive care unit.

Methods

The study group included 117 patients with a diagnosis of severe "viral COVID-19 pneumonia". Determination of NOS3 gene variants was performed using the PCR method. The probability of differences in the quantitative results were determined using ANOVA or Kruskal-Wallis test (depend of normality

SUBMITTER: Fishchuk L 

PROVIDER: S-EPMC10082643 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature