Flex Meta-Storms elucidates the microbiome local beta-diversity under specific phenotypes.

ABSTRACT:

Motivation

Beta-diversity quantitatively measures the difference among microbial communities thus enlightening the association between microbiome composition and environment properties or host phenotypes. The beta-diversity analysis mainly relies on distances among microbiomes that are calculated by all microbial features. However, in some cases, only a small fraction of members in a community plays crucial roles. Such a tiny proportion is insufficient to alter the overall distance, which is always missed by end-to-end comparison. On the other hand, beta-diversity pattern can also be interfered due to the data sparsity when only focusing on nonabundant microbes.

Results

Here, we develop Flex Meta-Storms (FMS) distance algorithm that implements the "local alignment" of microb

SUBMITTER: Zhang M 

PROVIDER: S-EPMC10082668 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature