Hepatocyte PPARγ contributes to the progression of non-alcoholic steatohepatitis in male and female obese mice.

ABSTRACT: Non-alcoholic steatohepatitis (NASH) is associated with obesity and increased expression of hepatic peroxisome proliferator-activated receptor γ (PPARγ). However, the relevance of hepatocyte PPARγ in NASH associated with obesity is still poorly understood. In this study, hepatocyte PPARγ was knocked out (Pparg^ΔHep) in male and female mice after the development of high-fat diet-induced obesity. The diet-induced obese mice were then maintained on their original diet or switched to a high fat, cholesterol, and fructose (HFCF) diet to induce NASH. Hepatic PPARγ expression was mostly derived from hepatocytes and increased by high fat diets. Pparg^ΔHep reduced HFCF-induced NASH progression without altering steatosis, reduced the expression of key genes involved in hepatic fi

SUBMITTER: Lee SM 

PROVIDER: S-EPMC10082675 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature