Clinical prognostic value of OSGIN2 in gastric cancer and its proliferative effect in vitro.

ABSTRACT: This study explored the promoting effect of oxidative stress-induced growth inhibitor family member 2(OSGIN2) on gastric cancer (GC) through public databases and in vitro experiments. The potential relationship between OSGIN2 expression, prognosis, functional enrichment of associated differential genes, immune infiltration, and mutational information in gastric cancer were comprehensively investigated using bioinformatics analysis. OSGIN2 was knocked down using small interfering RNA (siRNA) transfection for subsequent cell function testing. The results showed that gastric carcinoma cells and tissues contained high levels of OSGIN2, which was associated with a poor prognosis for GC patients. It was important in the cell cycle, autophagy, etc., and was related to a variety of tumor-related s

SUBMITTER: Wang P 

PROVIDER: S-EPMC10082810 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature