Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model.

ABSTRACT: Despite aggressive therapeutic regimens, glioblastoma (GBM) represents a deadly brain tumor with significant aggressiveness, radioresistance and chemoresistance, leading to dismal prognosis. Hypoxic microenvironment, which characterizes GBM, is associated with reduced therapeutic effectiveness. Moreover, current irradiation approaches are limited by uncertain tumor delineation and severe side effects that comprehensively lead to unsuccessful treatment and to a worsening of the quality of life of GBM patients. Proton beam offers the opportunity of reduced side effects and a depth-dose profile, which, unfortunately, are coupled with low relative biological effectiveness (RBE). The use of radiosensitizing agents, such as boron-containing molecules, enhances proton RBE and increases the effect

SUBMITTER: Cammarata FP 

PROVIDER: S-EPMC10082834 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature