Integrative analyses of ferroptosis and immune related biomarkers and the osteosarcoma associated mechanisms.

ABSTRACT: Osteosarcoma (OS) is the most common primary malignant bone tumor with high metastatic potential and relapse risk. To study the regulatory mechanism of the OS microenvironment, a complex regulatory network involving the ferroptosis- and immune response-related genes remains to be established. In the present study, we determined the effect of a comprehensive evaluation system established on the basis of ferroptosis- and immune-related genes on the immune status, related biomarkers, prognosis, and the potential regulatory networks underlying OS based on the TARGET and Gene Expression Omnibus databases that contain information on OS patients by bioinformatics analyses. We first characterized individual ferroptosis scores and immune scores through gene set variation analysis (GSVA) against TAR

SUBMITTER: Li G 

PROVIDER: S-EPMC10082853 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature