Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson's disease patients.

ABSTRACT:

Background

The sequence effect (SE) is characterized by the progressive decrement of movements and is often observed in Parkinson's disease (PD) patients. While acute effect of levodopa does not ameliorate the SE, the effect of long-term levodopa treatment for the SE remains unknown.

Objective

We aimed to elucidate the SEs during various gait conditions and their response to long-term levodopa treatment in drug-naïve PD patients.

Methods

Nineteen drug-naïve PD patients and 21 healthy controls were enrolled. Gait parameters were measured via wearable inertial sensors in the following conditions:1) straight walking, 2) circular walking: walking a circle of 1 m diameter in a clock-wise direction for 3 laps, 3) straight or circular walking under cognitive-motor dual-task

SUBMITTER: Ohara M 

PROVIDER: S-EPMC10082924 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature