Trial of Hybrid Closed-Loop Control in Young Children with Type 1 Diabetes.

ABSTRACT:

Background

Closed-loop control systems of insulin delivery may improve glycemic outcomes in young children with type 1 diabetes. The efficacy and safety of initiating a closed-loop system virtually are unclear.

Methods

In this 13-week, multicenter trial, we randomly assigned, in a 2:1 ratio, children who were at least 2 years of age but younger than 6 years of age who had type 1 diabetes to receive treatment with a closed-loop system of insulin delivery or standard care that included either an insulin pump or multiple daily injections of insulin plus a continuous glucose monitor. The primary outcome was the percentage of time that the glucose level was in the target range of 70 to 180 mg per deciliter, as measured by continuous glucose monitoring. Secondary outcomes included

SUBMITTER: Wadwa RP 

PROVIDER: S-EPMC10082994 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature