Serum metabolomics analysis reveals metabolite profile and key biomarkers of idiopathic membranous nephropathy.

ABSTRACT:

Background

Idiopathic membranous nephropathy (IMN) is an organ-specific autoimmune disease with multiple and complex pathogenic mechanisms. Currently, renal biopsy is considered the gold standard for diagnosing membranous nephropathy. However, there were limitations to the renal puncture biopsy, such as the relatively high cost, longer time consuming, and the risk of invasive procedures. We investigated the profile of serum metabolites in IMN patients based on the UHPLC-QE-MS metabolomics technique for exploring the potential disease biomarkers and clinical implementation.

Methods

In our research, we collected serum samples from healthy control (n = 15) and IMN patients (n = 25) to perform metabolomics analysis based on the UHPLC-QE-MS technique.

Result

SUBMITTER: Ye M 

PROVIDER: S-EPMC10083006 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature