Transcriptome and Proteome Profiling of Primary Human Gastric Interstitial Cells of Cajal Predicts Pacemaker Networks.

ABSTRACT:

Background/aims

Interstitial cells of Cajal (ICC) are specialized gastrointestinal (GI) pacemaker cells required for normal GI motility. Dysfunctions in ICC have been reported in patients with GI motility disorders, such as gastroparesis, who exhibit debilitating symptoms and greatly reduced quality of life. While the proteins, calcium-activated chloride channel anoctamin-1 (ANO1) and the receptor tyrosine kinase (KIT), are known to be expressed by human ICC, relatively little is known about the broad molecular circuitry underpinning human ICC functions. The present study therefore investigates the transcriptome and proteome of ANO1-expressing, KIT^low/CD45^-/CD11B^- ICC obtained from primary human gastric tissue.

Methods

Excess human gastric ti

SUBMITTER: Foong D 

PROVIDER: S-EPMC10083119 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature