Total Transit Time and Probiotic Persistence in Healthy Adults: A Pilot Study.

ABSTRACT:

Background/aims

Motility, stool characteristics, and microbiota composition are expected to modulate probiotics' passage through the gut but their effects on persistence after intake cessation remain uncharacterized. This pilot, open-label study aims at characterizing probiotic fecal detection parameters (onset, persistence, and duration) and their relationship with whole gut transit time (WGTT). Correlations with fecal microbiota composition are also explored.

Methods

Thirty healthy adults (30.4 ± 13.3 years) received a probiotic (30 × 10⁹ CFU/capsule/day, 2 weeks; containing Lactobacillus helveticus R0052, Lacticaseibacillus paracasei HA-108, Bifidobacterium breve HA-129, Bifidobacterium longum R0175, and Streptococcus thermophilus

SUBMITTER: Tremblay A 

PROVIDER: S-EPMC10083121 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature