Clinical Implications of Low Absolute Blood Eosinophil Count in the SPIROMICS COPD Cohort.

ABSTRACT:

Background

The Global Initiative for Chronic Obstructive Lung Disease (GOLD) considers blood eosinophil counts < 100 cells/μL (BEC_≤100) in people with COPD to predict poor inhaled corticosteroid (ICS) responsiveness. However, the BEC_≤100 phenotype is inadequately characterized, especially in advanced COPD.

Research question

Are there differences between GOLD group D patients with high BEC and those with low BEC regarding baseline characteristics and longitudinal outcomes?

Study design and methods

We used multivariable mixed models and logistic regression to contrast clinical characteristics and outcomes of BEC_≤100 vs BEC > 100 (BEC₁₀₀₊) in all subjects with COPD (n = 1,414) and GOLD group D subjects (n = 185) not receiving I

SUBMITTER: LeMaster WB 

PROVIDER: S-EPMC10083128 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature