Apolipoprotein E Gene Polymorphism Effects on Lipid Metabolism and Risk of Cerebral Infarction in Northwest Han Chinese Population.

ABSTRACT:

Background

The apolipoprotein E (ApoE) genetic variation may contribute to the development of Cerebral Infarction (CI). Serum lipid levels are known risk factors for CI, but the effect of the ApoE gene polymorphism on lipid metabolism remains unclear. This retrospective cohort study was designed to determine the role of ApoE genotypes in CI risk and the relationships between ApoE gene polymorphism and serum lipid levels among the population of northwest China.

Patients and methods

517 CI patients and 517 non-CI controls were enrolled in the study. Polymerase chain reaction and hybridization were utilized to determine the ApoE gene polymorphisms.

Results

The ε3/ε4 genotype and ε4 allele frequency were significantly higher in CI patients than in controls. When stratifie

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10083142 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature